Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

Ferroptosis is a specialized form of regulated cell death that is charactered by iron-dependent lethal lipid peroxidation, a process associated with multiple diseases. However, its role in the pathogenesis of intervertebral disc degeneration (IVDD) is rarely investigated. This study is aimed at inve...

Full description

Bibliographic Details
Main Authors:	Saideng Lu, Yu Song, Rongjin Luo, Shuai Li, Gaocai Li, Kun Wang, Zhiwei Liao, Bingjin Wang, Wencan Ke, Qian Xiang, Chao Chen, Xinghuo Wu, Yukun Zhang, Li Ling, Cao Yang
Format:	Article
Language:	English
Published:	Hindawi Limited 2021-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2021/6670497

Similar Items

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo
by: Zhiwei Liao, et al.
Published: (2021-01-01)

Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
by: Bingjin Wang, et al.
Published: (2021-01-01)

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration
by: Hai-Wei Chen, et al.
Published: (2021-01-01)

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
by: Shanmuganathan Rajasekaran, et al.
Published: (2020-08-01)

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?
by: J Guerrero, et al.
Published: (2021-06-01)

FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells
by: Rongjin Luo, et al.
Published: (2021-01-01)

Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
by: Purmessur, Devina
Published: (2008)

Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells
by: Qian Xiang, et al.
Published: (2020-01-01)

Characteristics and potentials of stem cells derived from human degenerated nucleus pulposus: potential for regeneration of the intervertebral disc
by: Xiao-Chuan Li, et al.
Published: (2017-06-01)

The influence of the nucleus pulposus on the stress distribution in the natural and prosthetic intervertebral disc
by: Karpiński Robert, et al.
Published: (2019-01-01)

Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging.
by: Xinyan Tang, et al.
Published: (2012-01-01)

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
by: Hui Che, et al.
Published: (2020-03-01)

Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo
by: Wang H, et al.
Published: (2020-11-01)

Effect of Nucleus Pulposus Denaturation and Anulus Fibrosus Injury on the Viscoelastic Properties of Intervertebral Disc
by: Mon-Chien Wang, et al.
Published: (2012)

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
by: Daisuke Sakai, et al.
Published: (2018-06-01)

Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in vivo
by: Huiyong Liu, et al.
Published: (2018-09-01)

Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration
by: Chensheng Qiu, et al.
Published: (2020-06-01)

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration
by: Yu Song, et al.
Published: (2018-10-01)

Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in an Organ Culture
by: Jia-Wen Zhan, et al.
Published: (2016-01-01)

Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study
by: Steven V. Beekmans, et al.
Published: (2018-03-01)

Evaluation of a novel surgical procedure for removal of the nucleus pulposus in lumbar intervertebral discs
by: Huemmer, Carmen
Published: (2012)

Removal of the nucleus pulposus from the intervertebral disc : effect on the response of the annulus fibrosus to compression
by: Meakin, Judith R.
Published: (1998)

Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGFβ Activation in Nucleus Pulposus Cells
by: Shufen Liu, et al.
Published: (2019-01-01)

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration
by: Chen Xu, et al.
Published: (2021-02-01)

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats
by: Qi Sun, et al.
Published: (2021-06-01)

LDHA-Mediated Glycolytic Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration
by: Longxi Wu, et al.
Published: (2021-01-01)

Degenerate intervertebral disc‐like pH induces a catabolic mechanoresponse in human nucleus pulposus cells
by: Nathan W. Hodson, et al.
Published: (2018-03-01)

Protective Effect of Polygonatum sibiricum Polysaccharides on Apoptosis, Inflammation, and Oxidative Stress in Nucleus Pulposus Cells of Rats with the Degeneration of the Intervertebral Disc
by: Zhaohui Zhai, et al.
Published: (2019-01-01)

Injectable Hydrogel Combined with Nucleus Pulposus-Derived Mesenchymal Stem Cells for the Treatment of Degenerative Intervertebral Disc in Rats
by: Feng Wang, et al.
Published: (2019-01-01)

FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc.
by: Zheng Wang, et al.
Published: (2016-01-01)

LncRNA MAGI2-AS3 is down-regulated in intervertebral disc degeneration and participates in the regulation of FasL expression in nucleus pulposus cells
by: Shuting Cui, et al.
Published: (2020-03-01)

Non-Coding RNA Extraction from Nucleus Pulposus of Intervertebral Discs with Subsequent Expression Profiling
by: I. F. Gareev, et al.
Published: (2020-07-01)

Regenerative and immunogenic characteristics of cultured nucleus pulposus cells from human cervical intervertebral discs.
by: Stefan Stich, et al.
Published: (2015-01-01)

Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc.
by: Chitra Lekha Dahia, et al.
Published: (2012-01-01)

Comparison of the Production of Extracellular Matrix in Nucleus Pulposus of Intervertebral Disc in Alginate and Chitosan-Gelatin Scaffolds
by: Masoud Ghorbani, et al.
Published: (2013-04-01)

Transcriptional Profiling Uncovers Biologically Significant RNAs and Regulatory Networks in Nucleus Pulposus from Intervertebral Disc Degeneration Patients
by: Yuanyuan Chen, et al.
Published: (2021-01-01)

Acid-sensing ion channel 1a regulates the survival of nucleus pulposus cells in the acidic environment of degenerated intervertebral discs
by: Feng Cai, et al.
Published: (2016-08-01)

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration
by: Jin Feng Ma, et al.
Published: (2016-01-01)

Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in Ex vivo Organ Culture
by: Li-Guo Zhu, et al.
Published: (2016-01-01)

Micro Fragmented Adipose Tissue Promotes the Matrix Synthesis Function of Nucleus Pulposus Cells and Regenerates Degenerated Intervertebral Disc in a Pig Model
by: Xiaopeng Zhou, et al.
Published: (2020-02-01)