A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
Strontium-82 is produced by proton activation of a rubidium chloride target in an accelerator or cyclotron and purified by ion exchange chromatography. The Strontrium-82 is used in Cardigen generators to produce Rubidium-82 for cardiac imaging. Quality control testing of the purified Strontium-82 is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-05-01
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| Series: | Chemosensors |
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| Online Access: | http://www.mdpi.com/2227-9040/4/2/9 |
| Summary: | Strontium-82 is produced by proton activation of a rubidium chloride target in an accelerator or cyclotron and purified by ion exchange chromatography. The Strontrium-82 is used in Cardigen generators to produce Rubidium-82 for cardiac imaging. Quality control testing of the purified Strontium-82 is performed with Inductively Coupled Plasma-Optical Emission spectroscopy (ICP-OES) and gamma spectroscopy. To meet Department of Energy specifications for HCl molarity the purified Strontium-82 solution needs to be tested to determine if the isotope is in the 0.05–0.5 M HCl range. This manuscript reports a simple HCl molarity test to determine if the purified Strontium-82 solution meets specifications. Validation of the assay was performed by evaluating all solutions associate with Strontium-82 processing. |
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| ISSN: | 2227-9040 |