Are human dental pulp stem cells the future of neurodegenerative diseases and nerve injury therapy?*

• Main Authors: Julia Bar, Iwona Deszcz, Anna Lis-Nawara, Piotr Grelewski
• Format: Article
• Language: English
• Published: Index Copernicus International S.A. 2020-10-01
• Series: Postępy Higieny i Medycyny Doświadczalnej
• Subjects: dental pulp stem cells; neurodegenerative diseases; peripheral nerve injury; stem cell therapy
• Online Access: http://phmd.pl/gicid/01.3001.0014.4521

This review summarizes results from in vitro and in vivo studies which provide evidence that human dental pulp stem cells (hDPSCs) might be a novel treatment strategy for nervous system injuries and neurodegenerative diseases because of their high potential for neurogenic differentiation and secretion of neuron-related trophic factors. It is also worth underlining that hDPSCs are neural crest-derived cells that possess biological properties of mesenchymal stem cells (MSCs). Induced hDPSCs have a high ability to differentiate into neuron-like cells, which show functional activity. hDPSCs express immunomodulatory factors that enhance regeneration and repair of nerve injury. These specific features of undifferentiated and differentiated hDPSCs make these cells promising for the therapy of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s diseases, stroke, spinal cord injury as well as peripheral nerve injury. Recently, investigators propose that the tissue engineering technology, including scaffold, stem cells and growth factor, should provide a new strategy for spinal cord and peripheral nerve injury treatment. hDPSCs should be considered as a good choice for peripheral nerve injury therapy, because they have better potential to differentiate into neural and glial cells than stem cells coming from other sources through the expression of neuronal makers and wide range of neurotropic factors secretion. Unique properties of hDPSCs, such as high proliferation rate, trophic factors expression and stronger neuroprotective effects, indicate that these stem cells may be beneficial in neural disease therapy.