NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-κB/COX-2/PG pathway

NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-κB/COX-2/PG pathway

Abstract Background Primary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activation and PD is still unclear. Methods To investigate the potential role o...

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Bibliographic Details
Main Authors: Biao Tang, Dan Liu, Lingyu Chen, Yu Liu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Inflammation
Subjects:
Primary dysmenorrhea
Nucleotide-binding oligomerization domain-like receptor protein 3
Nuclear factor kappa B
Cyclooxygenase-2
Prostaglandins
Online Access:http://link.springer.com/article/10.1186/s12950-020-00251-7

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