Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may reg...

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Main Authors:	Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18680-6

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spelling	doaj-e246ffb072c949edb55bfd5a4212656f2021-10-03T11:51:26ZengNature Publishing GroupNature Communications2041-17232020-10-0111111610.1038/s41467-020-18680-6Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humansQian-Qian Sha0Wei Zheng1Yun-Wen Wu2Sen Li3Lei Guo4Shuoping Zhang5Ge Lin6Xiang-Hong Ou7Heng-Yu Fan8Fertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General HospitalClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYALife Sciences Institute, Zhejiang UniversityFertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General HospitalFertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General HospitalClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYAClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYAFertility Preservation Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General HospitalLife Sciences Institute, Zhejiang UniversityHow maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may regulate such early development.https://doi.org/10.1038/s41467-020-18680-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qian-Qian Sha Wei Zheng Yun-Wen Wu Sen Li Lei Guo Shuoping Zhang Ge Lin Xiang-Hong Ou Heng-Yu Fan
spellingShingle	Qian-Qian Sha Wei Zheng Yun-Wen Wu Sen Li Lei Guo Shuoping Zhang Ge Lin Xiang-Hong Ou Heng-Yu Fan Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans Nature Communications
author_facet	Qian-Qian Sha Wei Zheng Yun-Wen Wu Sen Li Lei Guo Shuoping Zhang Ge Lin Xiang-Hong Ou Heng-Yu Fan
author_sort	Qian-Qian Sha
title	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_short	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_full	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_fullStr	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_full_unstemmed	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_sort	dynamics and clinical relevance of maternal mrna clearance during the oocyte-to-embryo transition in humans
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may regulate such early development.
url	https://doi.org/10.1038/s41467-020-18680-6
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Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

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