Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis

Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis

Purpose: To evaluate the potential added value of integrating anti-apoptotic molecules for improving the anti-tumor activity of CAR-T cells. Methods: Four small molecules inhibiting apoptosis were tested for their ability to prevent activated induced CAR-T cell death. Five CD20-targeting, CD137 (4-1...

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Bibliographic Details
Main Authors: Haiyong Wang, Ping Han, Xinyue Qi, Fanlin Li, Min Li, Lilv Fan, Huihui Zhang, Xiaoqing Zhang, Xuanming Yang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
Bcl-2
CAR-T
lymphoma
CD20
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/13/2/197

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