Large-Scale Production and Protein Engineering of G Protein-Coupled Receptors for Structural Studies

Large-Scale Production and Protein Engineering of G Protein-Coupled Receptors for Structural Studies

Structural studies of G protein-coupled receptors (GPCRs) gave insights into molecular mechanisms of their action and contributed significantly to molecular pharmacology. This is primarily due to technical advances in protein engineering, production and crystallization of these important receptor ta...

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Bibliographic Details
Main Authors: Dalibor eMilić, Dmitry B. Veprintsev
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
Isotope Labeling
Protein Engineering
Expression
purification
G protein-coupled receptor (GPCR)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00066/full

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