| Summary: | As a non-invasive technology, photodynamic therapy (PDT) has been widely studied for tumor ablation and infection control. In recent years, nanoparticle (NP)-based PDT has attracted significant interest in improving wound healing. By photodynamically tuning the temperature of the wounds, NP-based PDT may promote cell proliferation and generate reactive oxygen species, thereby playing a beneficial role in tissue regeneration. In this mini review, the recent pioneering work of NP-based PDT in enhancing wound healing of skin, bone, and cartilage is presented. Various types of light-to-heat and magnetic field-to-heat NPs with encouraging therapeutic effects on wound healing are detailed and compared. The PDT temperatures that can be used for wound healing are described. The pros and cons of NP-based PDT are summarized with special attention to the basic requirements of NPs to be used for wound healing treatments. Future research directions on how to decrease the non-specific interactions while increasing PDT efficiency are also discussed.
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