Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer

Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer

The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been eluci...

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Main Authors: Maria Smolle, Stefan Uranitsch, Armin Gerger, Martin Pichler, Johannes Haybaeck
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
lncRNA
cancer
molecular tumor pathogenesis
Online Access:http://www.mdpi.com/1422-0067/15/8/13993
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spelling doaj-e2338ed8d9024d8d81262c3ad81698572020-11-25T01:06:23ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-08-01158139931401310.3390/ijms150813993ijms150813993Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal CancerMaria Smolle0Stefan Uranitsch1Armin Gerger2Martin Pichler3Johannes Haybaeck4Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, AustriaDepartment of Surgery, St John of God Hospital Graz, Marschallgasse 12, A-8020 Graz, AustriaDivision of Oncology, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, AustriaDivision of Oncology, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, AustriaInstitute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, AustriaThe latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.http://www.mdpi.com/1422-0067/15/8/13993colorectal cancerlncRNAcancermolecular tumor pathogenesis
collection DOAJ
language English
format Article
sources DOAJ
author Maria Smolle
Stefan Uranitsch
Armin Gerger
Martin Pichler
Johannes Haybaeck
spellingShingle Maria Smolle
Stefan Uranitsch
Armin Gerger
Martin Pichler
Johannes Haybaeck
Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
International Journal of Molecular Sciences
colorectal cancer
lncRNA
cancer
molecular tumor pathogenesis
author_facet Maria Smolle
Stefan Uranitsch
Armin Gerger
Martin Pichler
Johannes Haybaeck
author_sort Maria Smolle
title Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_short Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_full Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_fullStr Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_full_unstemmed Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
title_sort current status of long non-coding rnas in human cancer with specific focus on colorectal cancer
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2014-08-01
description The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.
topic colorectal cancer
lncRNA
cancer
molecular tumor pathogenesis
url http://www.mdpi.com/1422-0067/15/8/13993
work_keys_str_mv AT mariasmolle currentstatusoflongnoncodingrnasinhumancancerwithspecificfocusoncolorectalcancer
AT stefanuranitsch currentstatusoflongnoncodingrnasinhumancancerwithspecificfocusoncolorectalcancer
AT armingerger currentstatusoflongnoncodingrnasinhumancancerwithspecificfocusoncolorectalcancer
AT martinpichler currentstatusoflongnoncodingrnasinhumancancerwithspecificfocusoncolorectalcancer
AT johanneshaybaeck currentstatusoflongnoncodingrnasinhumancancerwithspecificfocusoncolorectalcancer
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