Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma

Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma

Cancer stem cells (CSCs) drive tumour spread and therapeutic resistance, and can undergo epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) to switch between epithelial and post-EMT sub-populations. Examining oral squamous cell carcinoma (OSCC), we now show tha...

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Bibliographic Details
Main Authors: Adrian Biddle, Luke Gammon, Xiao Liang, Daniela Elena Costea, Ian C. Mackenzie
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:EBioMedicine
Subjects:
Cancer
Stem cell
CSC
EMT
Plasticity
Therapy
Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300056

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