The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in vivo

The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in vivo

Objective: The miR-200–Zeb1 axis regulates the epithelial-to-mesenchymal transition (EMT), differentiation, and resistance to apoptosis. A better understanding of these processes in diabetes is highly relevant, as β-cell dedifferentiation and apoptosis contribute to the loss of functional β-cell mas...

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Bibliographic Details
Main Authors: Alexandra C. Title, Pamuditha N. Silva, Svenja Godbersen, Lynn Hasenöhrl, Markus Stoffel
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
β-cell dedifferentiation
Epithelial-to-mesenchymal transition
Double-negative feedback loop
Islet aggregation
ER stress
microRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001125

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