Analysis of predictive parameters for the development of radiation-induced pneumonitis

Introduction: Prevention and effective treatment of radiation-induced pneumonitis (RP) could facilitate greater use of radiation therapy (RT) for lung cancer. The purpose of this study was to determine clinical parameters useful for early prediction of RP. Methods: Blood sampling, pulmonary function...

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Main Authors: Toru Yamagishi, Norio Kodaka, Yoshiyuki Kurose, Kayo Watanabe, Chihiro Nakano, Kumiko Kishimoto, Takeshi Oshio, Kumiko Niitsuma, Hiroto Matsuse
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Annals of Thoracic Medicine
Subjects:
Online Access:http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2017;volume=12;issue=4;spage=252;epage=258;aulast=Yamagishi
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spelling doaj-e228c994d8684f53be981bf32d737ace2020-11-24T22:38:42ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572017-01-0112425225810.4103/atm.ATM_355_16Analysis of predictive parameters for the development of radiation-induced pneumonitisToru YamagishiNorio KodakaYoshiyuki KuroseKayo WatanabeChihiro NakanoKumiko KishimotoTakeshi OshioKumiko NiitsumaHiroto MatsuseIntroduction: Prevention and effective treatment of radiation-induced pneumonitis (RP) could facilitate greater use of radiation therapy (RT) for lung cancer. The purpose of this study was to determine clinical parameters useful for early prediction of RP. Methods: Blood sampling, pulmonary function testing, chest computed tomography, and bronchoalveolar lavage (BAL) were performed in patients with pathologically confirmed lung cancer who had completed ≥60 Gy of RT, at baseline, shortly after RT, and at 1 month posttreatment. Results: By 3 months post-RT, 11 patients developed RP (RP group) and the remaining 11 patients did not (NRP group). RT significantly increased total cell counts and alveolar macrophages in BAL of the NRP group, whereas lymphocyte count was increased in both groups. Matrix metallopeptidase-9 (MMP-9) increased and vascular endothelial growth factor decreased significantly in the BAL fluid (BALF) of the RP group following RT. Serum surfactant protein D (SP-D) increased significantly in the NRP group. SP-D in BALF from the RP group increased significantly with a subsequent increase in serum SP-D. Pulmonary dilution decreased similarly in both groups of patients. Conclusions: Increased SP-D in BALF, rather than that in serum, could be useful biomarkers in predicting RP. The MMP-9 in BALF might play a role in the pathogenesis of RP. Pulmonary dilution test may not be predictive of the development of RP.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2017;volume=12;issue=4;spage=252;epage=258;aulast=YamagishiBronchoalveolar lavagematrix metallopeptidase-9radiation-induced pneumonitissurfactant protein Dvascular endothelial growth factor
collection DOAJ
language English
format Article
sources DOAJ
author Toru Yamagishi
Norio Kodaka
Yoshiyuki Kurose
Kayo Watanabe
Chihiro Nakano
Kumiko Kishimoto
Takeshi Oshio
Kumiko Niitsuma
Hiroto Matsuse
spellingShingle Toru Yamagishi
Norio Kodaka
Yoshiyuki Kurose
Kayo Watanabe
Chihiro Nakano
Kumiko Kishimoto
Takeshi Oshio
Kumiko Niitsuma
Hiroto Matsuse
Analysis of predictive parameters for the development of radiation-induced pneumonitis
Annals of Thoracic Medicine
Bronchoalveolar lavage
matrix metallopeptidase-9
radiation-induced pneumonitis
surfactant protein D
vascular endothelial growth factor
author_facet Toru Yamagishi
Norio Kodaka
Yoshiyuki Kurose
Kayo Watanabe
Chihiro Nakano
Kumiko Kishimoto
Takeshi Oshio
Kumiko Niitsuma
Hiroto Matsuse
author_sort Toru Yamagishi
title Analysis of predictive parameters for the development of radiation-induced pneumonitis
title_short Analysis of predictive parameters for the development of radiation-induced pneumonitis
title_full Analysis of predictive parameters for the development of radiation-induced pneumonitis
title_fullStr Analysis of predictive parameters for the development of radiation-induced pneumonitis
title_full_unstemmed Analysis of predictive parameters for the development of radiation-induced pneumonitis
title_sort analysis of predictive parameters for the development of radiation-induced pneumonitis
publisher Wolters Kluwer Medknow Publications
series Annals of Thoracic Medicine
issn 1817-1737
1998-3557
publishDate 2017-01-01
description Introduction: Prevention and effective treatment of radiation-induced pneumonitis (RP) could facilitate greater use of radiation therapy (RT) for lung cancer. The purpose of this study was to determine clinical parameters useful for early prediction of RP. Methods: Blood sampling, pulmonary function testing, chest computed tomography, and bronchoalveolar lavage (BAL) were performed in patients with pathologically confirmed lung cancer who had completed ≥60 Gy of RT, at baseline, shortly after RT, and at 1 month posttreatment. Results: By 3 months post-RT, 11 patients developed RP (RP group) and the remaining 11 patients did not (NRP group). RT significantly increased total cell counts and alveolar macrophages in BAL of the NRP group, whereas lymphocyte count was increased in both groups. Matrix metallopeptidase-9 (MMP-9) increased and vascular endothelial growth factor decreased significantly in the BAL fluid (BALF) of the RP group following RT. Serum surfactant protein D (SP-D) increased significantly in the NRP group. SP-D in BALF from the RP group increased significantly with a subsequent increase in serum SP-D. Pulmonary dilution decreased similarly in both groups of patients. Conclusions: Increased SP-D in BALF, rather than that in serum, could be useful biomarkers in predicting RP. The MMP-9 in BALF might play a role in the pathogenesis of RP. Pulmonary dilution test may not be predictive of the development of RP.
topic Bronchoalveolar lavage
matrix metallopeptidase-9
radiation-induced pneumonitis
surfactant protein D
vascular endothelial growth factor
url http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2017;volume=12;issue=4;spage=252;epage=258;aulast=Yamagishi
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