Functional Analysis of Rare Genetic Variants in the Negative Regulator of Intracellular Calcium Signaling RCAS/SLC10A7

Functional Analysis of Rare Genetic Variants in the Negative Regulator of Intracellular Calcium Signaling RCAS/SLC10A7

The solute carrier family 10 member SLC10A7 is a negative regulator of intracellular calcium signaling (RCAS). In cell culture, SLC10A7 expression is negatively correlated with store-operated calcium entry (SOCE) via the plasma membrane. SLC10A7-deficient cells have significantly increased calcium i...

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Bibliographic Details
Main Authors: Marie Wannowius, Emre Karakus, Joachim Geyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
SLC10A7
RCAS
calcium signaling
STIM
co-localization
rare genetic variant
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.741946/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.741946/full

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