The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on. Specific side-chain cholesterol oxidation products of the oxysterols family have been shown to inhibit a large variety of both envelo...

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Bibliographic Details
Main Authors: Alessandro Marcello, Andrea Civra, Rafaela Milan Bonotto, Lais Nascimento Alves, Sreejith Rajasekharan, Chiara Giacobone, Claudio Caccia, Roberta Cavalli, Marco Adami, Paolo Brambilla, David Lembo, Giuseppe Poli, Valerio Leoni
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Coronavirus
SARS-CoV-2
COVID-19
HCoV-OC43
Cholesterol
Oxysterols
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308879

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