Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

Parkinson’s disease (PD) is a neurodegenerative disease that affects substantia nigra dopamine neurons. Many studies have documented the role of oxidative stress and angiogenesis in the pathogenesis of PD. Metformin (MTF) is an antidiabetic medication and AMP-activated protein kinase (AMPK) regulato...

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Bibliographic Details
Main Authors: Sabah H. El-Ghaiesh, Hoda I. Bahr, Afaf T. Ibrahiem, Doaa Ghorab, Suliman Y. Alomar, Noha E. Farag, Sawsan A. Zaitone
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
AMPK-FOXO3
cleaved caspase 3
metformin
oxidative stress
rotenone-induced parkinsonism
vascular endothelial growth factor
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00084/full

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