Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients

A great disappointment in head and neck cancer surgery is that 10–30% of head and neck squamous cell carcinoma (HNSCC) patients develop local recurrences despite histopathologically tumor-free surgical margins. These recurrences result from either minimal residual cancer (MRC) or preneoplastic lesio...

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Main Authors:	A. Peggy Graveland, Michiel de Maaker, Boudewijn J. M. Braakhuis, Remco de Bree, Simone E. J. Eerenstein, Elisabeth Bloemena, C. René Leemans, Ruud H. Brakenhoff
Format:	Article
Language:	English
Published:	Hindawi Limited 2009-01-01
Series:	Cellular Oncology
Online Access:	http://dx.doi.org/10.3233/CLO-2009-0474

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spelling	doaj-e20bc508bf6b4c31bce1690884501b5d2020-11-24T22:57:48ZengHindawi LimitedCellular Oncology1570-58701875-86062009-01-0131431732810.3233/CLO-2009-0474Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer PatientsA. Peggy Graveland0Michiel de Maaker1Boudewijn J. M. Braakhuis2Remco de Bree3Simone E. J. Eerenstein4Elisabeth Bloemena5C. René Leemans6Ruud H. Brakenhoff7Department of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Otolaryngology/Head–Neck Surgery, VU University Medical Center, Amsterdam, The NetherlandsA great disappointment in head and neck cancer surgery is that 10–30% of head and neck squamous cell carcinoma (HNSCC) patients develop local recurrences despite histopathologically tumor-free surgical margins. These recurrences result from either minimal residual cancer (MRC) or preneoplastic lesions that remain behind after tumor resection. Distinguishing MRC from preneoplasic lesions is important to tailor postoperative radiotherapy more adequately. Here we investigated the suitability of quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) using human Ly-6D (hLy-6D) transcripts as molecular marker to detect MRC in surgical margins.http://dx.doi.org/10.3233/CLO-2009-0474
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A. Peggy Graveland Michiel de Maaker Boudewijn J. M. Braakhuis Remco de Bree Simone E. J. Eerenstein Elisabeth Bloemena C. René Leemans Ruud H. Brakenhoff
spellingShingle	A. Peggy Graveland Michiel de Maaker Boudewijn J. M. Braakhuis Remco de Bree Simone E. J. Eerenstein Elisabeth Bloemena C. René Leemans Ruud H. Brakenhoff Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients Cellular Oncology
author_facet	A. Peggy Graveland Michiel de Maaker Boudewijn J. M. Braakhuis Remco de Bree Simone E. J. Eerenstein Elisabeth Bloemena C. René Leemans Ruud H. Brakenhoff
author_sort	A. Peggy Graveland
title	Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients
title_short	Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients
title_full	Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients
title_fullStr	Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients
title_full_unstemmed	Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients
title_sort	molecular detection of minimal residual cancer in surgical margins of head and neck cancer patients
publisher	Hindawi Limited
series	Cellular Oncology
issn	1570-5870 1875-8606
publishDate	2009-01-01
description	A great disappointment in head and neck cancer surgery is that 10–30% of head and neck squamous cell carcinoma (HNSCC) patients develop local recurrences despite histopathologically tumor-free surgical margins. These recurrences result from either minimal residual cancer (MRC) or preneoplastic lesions that remain behind after tumor resection. Distinguishing MRC from preneoplasic lesions is important to tailor postoperative radiotherapy more adequately. Here we investigated the suitability of quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) using human Ly-6D (hLy-6D) transcripts as molecular marker to detect MRC in surgical margins.
url	http://dx.doi.org/10.3233/CLO-2009-0474
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Molecular Detection of Minimal Residual Cancer in Surgical Margins of Head and Neck Cancer Patients

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