Relationship between miR-100 expression in cervical cancer tissue and cisplatin resistance

• Main Authors: Yan-Fei Lu, Rui Chen, Guo-Qiang Chen
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Cervical cancer Cisplatin Drug resistance miR-100 Cell cycle
• Online Access: http://www.hnykdxxb.com/PDF/201709/26.pdf

Objective: To study the relationship between miR-100 expression in cervical cancer tissue and cisplatin resistance. Methods: A total of 107 cases of cervical cancer tissues from those who received cisplatin chemotherapy in Huanggan Central Hospital between May 2013 and October 2016 were collected as the clinical samples and divided into chemotherapyresponsive cisplatin-sensitive cervical cancer tissue and chemotherapy-irresponsive cisplatinsensitive cervical cancer tissue according to the curative effect of chemotherapy. The miR- 100 expression as well as the expression of drug resistance-related genes, cell cycle-related genes and cell invasion-related genes was determined. Results: The miR-100 expression in cisplatin-resistant cervical cancer tissue was significantly lower than that in cisplatin-sensitive cervical cancer tissue while Nek2, P-gp, GST-π, Topo-II, SP2, CyclinD1, CyclinG1, CDK4, CDK5, MMP1, PAR1, RbAp48, Vimentin and N-cadherin expression were significantly higher than those in cisplatin-sensitive cervical cancer tissue; the miR-100 expression was negatively correlated with Nek2, P-gp, GST-π, Topo-II, SP2, CyclinD1, CyclinG1, CDK4, CDK5, MMP1, PAR1, RbAp48, Vimentin and N-cadherin expression. Conclusion: The lower expression of miR-100 in cervical cancer tissue is closely associated with cisplatin resistance.