In vitro effect of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+, K+-ATPase

In vitro effect of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+, K+-ATPase

The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significant...

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Bibliographic Details
Main Authors: Anne Caroline Candido Gomes, Luzia da Silva Sampaio, Paulo André da Silva, Marcelo Einicker Lamas, Cassia Mônica Sakuragui, Cleber Bomfim Barreto Junior, Naomi Kato Simas, Ricardo Machado Kuster
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2014-01-01
Series:Química Nova
Subjects:
Syngonium podophyllum
Araceae
Isoschaftoside
enzyme inhibition
renal Na+, K+-ATPase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000006&lng=en&tlng=en
Description
Summary:The present study aimed to investigate the in vitro effects of isoschaftoside isolated from Syngonium podophyllum on pig kidney Na+,K+-ATPase. The Na+, K+-ATPase activity was determined by colorimetric measurement of inorganic phosphate (Pi), resulting from ATP hydrolysis. Isoschaftoside significantly decreased the renal Na+, K+-ATPase activity at the highest concentration as well as at a lower concentration. Our work suggests that isoschaftoside is a promising compound for the treatment of hypertension.
ISSN:1678-7064

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