Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

Medial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour. Here, the authors show that MEC lesioned animals show intact replay after an epoch of rats running on a linear track, while...

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Main Authors: Alireza Chenani, Marta Sabariego, Magdalene I. Schlesiger, Jill K. Leutgeb, Stefan Leutgeb, Christian Leibold
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09280-0
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spelling doaj-e1eb1c523e274f00922102f594a261db2021-05-11T11:41:36ZengNature Publishing GroupNature Communications2041-17232019-03-0110111310.1038/s41467-019-09280-0Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortexAlireza Chenani0Marta Sabariego1Magdalene I. Schlesiger2Jill K. Leutgeb3Stefan Leutgeb4Christian Leibold5Department Biology II, Ludwig-Maximilians-Universität MünchenNeurobiology Section and Center for Neural Circuits and Behavior, University of California, San DiegoNeurobiology Section and Center for Neural Circuits and Behavior, University of California, San DiegoNeurobiology Section and Center for Neural Circuits and Behavior, University of California, San DiegoNeurobiology Section and Center for Neural Circuits and Behavior, University of California, San DiegoDepartment Biology II, Ludwig-Maximilians-Universität MünchenMedial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour. Here, the authors show that MEC lesioned animals show intact replay after an epoch of rats running on a linear track, while replay during the behavioral epoch is reduced.https://doi.org/10.1038/s41467-019-09280-0
collection DOAJ
language English
format Article
sources DOAJ
author Alireza Chenani
Marta Sabariego
Magdalene I. Schlesiger
Jill K. Leutgeb
Stefan Leutgeb
Christian Leibold
spellingShingle Alireza Chenani
Marta Sabariego
Magdalene I. Schlesiger
Jill K. Leutgeb
Stefan Leutgeb
Christian Leibold
Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
Nature Communications
author_facet Alireza Chenani
Marta Sabariego
Magdalene I. Schlesiger
Jill K. Leutgeb
Stefan Leutgeb
Christian Leibold
author_sort Alireza Chenani
title Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
title_short Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
title_full Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
title_fullStr Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
title_full_unstemmed Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
title_sort hippocampal ca1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Medial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour. Here, the authors show that MEC lesioned animals show intact replay after an epoch of rats running on a linear track, while replay during the behavioral epoch is reduced.
url https://doi.org/10.1038/s41467-019-09280-0
work_keys_str_mv AT alirezachenani hippocampalca1replaybecomeslessprominentbutmorerigidwithoutinputsfrommedialentorhinalcortex
AT martasabariego hippocampalca1replaybecomeslessprominentbutmorerigidwithoutinputsfrommedialentorhinalcortex
AT magdaleneischlesiger hippocampalca1replaybecomeslessprominentbutmorerigidwithoutinputsfrommedialentorhinalcortex
AT jillkleutgeb hippocampalca1replaybecomeslessprominentbutmorerigidwithoutinputsfrommedialentorhinalcortex
AT stefanleutgeb hippocampalca1replaybecomeslessprominentbutmorerigidwithoutinputsfrommedialentorhinalcortex
AT christianleibold hippocampalca1replaybecomeslessprominentbutmorerigidwithoutinputsfrommedialentorhinalcortex
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