Sialic Acid and Sialidase Activity in Acute Stroke

Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, resulting in a disruption of cerebral blood flow with subsequent tissue damage. It is well known that erythrocytes have a large amount of sialic acid and could represent a model to investigate changes occurring in a pathology...

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Bibliographic Details
Main Authors: L. Nanetti, A. Vignini, F. Raffaelli, R. Taffi, M. Silvestrini, L. Provinciali, L. Mazzanti
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2008/613272
Description
Summary:Stroke is a heterogeneous syndrome caused by multiple disease mechanisms, resulting in a disruption of cerebral blood flow with subsequent tissue damage. It is well known that erythrocytes have a large amount of sialic acid and could represent a model to investigate changes occurring in a pathology like stroke. The aim of this study was to investigate a possible relationship among erythrocyte membrane, plasma and sialic acid content. The possible impact of the sialic acid content and the activity of sialidase on stroke severity was also evaluated.
ISSN:0278-0240
1875-8630