Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats

• Main Authors: Gholamreza Houshmand, Shahram Tarahomi, Ardeshir Arzi, Mehdi Goudarzi, Mohammad Bahadoram, Mohammadreza Rashidi-Nooshabadi
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2016-06-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: parkinsonian disorders; muscle rigidity; antioxidants; leguminoseae
• Online Access: https://jcdr.net/articles/PDF/7977/17813_CE(RA1)_F(T)_PF1(Vsu_Om)_PFA(AK)_PF2(PAG).pdf

Introduction: Parkinsonism is a neurodegenerative disease that is defined by certain symptoms such as muscle rigidity, impaired movement, catatonia, tremor and disorientation of body. Aim: The aim was to investigate the effect of red lentil extract on perphenazine-induced Catatonia in model of rat. Materials and Methods: This experimental study was done on 48 male albino rats (weight 180–200g) of the Sprague-Dawley strain. Animals were randomly divided into six groups and were pre-treated with a single dose of red lentil extract (200, 400, 800 and 1000 mg/kg), most effective dose of bromocriptine (30mg/ kg) and normal saline (5ml/kg) via intraperitoneal (IP) route. perphenazine (5 mg/kg) was after 30 minutes, administered (IP) to induce catatonia. The scoring method of Morpurgo was used to determine the muscular rigidity of animals. Results: The results showed that the 200mg/kg red lentil extract treated group had no significant reduction in catatonic responses after perphenazine administration in comparison with control group while the groups that received 800 and 1000mg/ kg of red lentil extract showed significant difference (p<0.05) at all the time points. Conclusion: The results revealed that hydroalcoholic extract of red lentil has protective effect on Catatonia induced by perphenazine in rats. So this extract may be probably beneficial for catatonia in Parkinsonism.