Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection

Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection

RationaleProtein kinase D (PKD) is a serine/threonine kinase family that is involved in a wide array of signaling pathways. Although PKD has been implicated in immune responses, relatively little is known about the function of PKD in the lung or during viral infections.ObjectivesWe investigated the...

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Bibliographic Details
Main Authors: Janelle M. Veazey, Sophia I Eliseeva, Sara E. Hillman, Kristie Stiles, Timothy R. Smyth, Charlotte E. Morrissey, Erika J. Tillotson, Dave J. Topham, Timothy J. Chapman, Steve N. Georas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
Airway epithelial barrier
innate immuity
Antiviral immune response
respiratory tract infections
Protein Kinase D
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.580401/full

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