CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/13

CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/13

The arachidonic acid-cytochrome P450 2J2-epoxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular system. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac fibrosis from the perspective of cardiac fibroblast...

Full description

Bibliographic Details
Main Authors:	Zuowen He, Yong Yang, Zheng Wen, Chen Chen, Xizhen Xu, Yanfang Zhu, Yan Wang, Dao Wen Wang
Format:	Article
Language:	English
Published:	Elsevier 2017-07-01
Series:	Journal of Lipid Research
Subjects:	cytochrome P450 2J2 cardiac fibrosis cardiac fibroblast α subunits of G12 family G proteins angiotensin II
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520335859

Similar Items

The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling
by: Jinsheng Lai, et al.
Published: (2021-02-01)

CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response
by: Chi Zhou, et al.
Published: (2016-07-01)

CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice[S]
by: Zhejun Cai, et al.
Published: (2013-05-01)

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury
by: Gang Zhao, et al.
Published: (2012-03-01)

ORGANIZATION AND EVOLUTION OF THE CYP2A-T GENE SUBFAMILY CLUSTER IN RODENTS, AND A COMPARISON TO THE SYNTENIC HUMAN CLUSTER
by: Wang, Haoyi
Published: (2003)

Comparison of CYP2C9 Activity in Ethiopian and Non-Ethiopian Jews Using Phenytoin as a Probe
by: Zahi Abu Ghosh, et al.
Published: (2020-09-01)

Generation and Characterization of CYP2E1-Overexpressing HepG2 Cells to Study the Role of CYP2E1 in Hepatic Hypoxia-Reoxygenation Injury
by: Alwadei, N., et al.
Published: (2023)

Inside epoxyeicosatrienoic acids and cardiovascular disease
by: Stefania eTacconelli, et al.
Published: (2014-11-01)

The Functional Role of Zinc Finger E Box-Binding Homeobox 2 (Zeb2) in Promoting Cardiac Fibroblast Activation
by: Fahmida Jahan, et al.
Published: (2018-10-01)

Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro
by: Jan Frank, et al.
Published: (2006-12-01)

Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming
by: Emre Bektik, et al.
Published: (2019-07-01)

Cardiac Fibroblasts Mediate a Sexually Dimorphic Fibrotic Response to β‐Adrenergic Stimulation
by: Angela K. Peter, et al.
Published: (2021-06-01)

14,15-Epoxyeicosatrienoic Acid Suppresses Cigarette Smoke Extract-Induced Apoptosis in Lung Epithelial Cells by Inhibiting Endoplasmic Reticulum Stress
by: Ganggang Yu, et al.
Published: (2015-05-01)

Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog
by: Manish B. Shah, et al.
Published: (2018-03-01)

CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion
by: Wenshu Chen, et al.
Published: (2014-05-01)

Untersuchungen zur Biotransformation und Toxizität mit der Hepatomzellinie Hep G2 im Vergleich zu Primärkulturen der Wistarratte
by: Mühlenfeld, Katrin
Published: (1999)

Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-β1 Signaling
by: Allen Sam Titus, et al.
Published: (2021-08-01)

Investigations of the biocatalytic activity of human P450 2D6
by: Zhao, Jin, 1975-
Published: (2007)

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations
by: Ann K. Daly, et al.
Published: (2017-12-01)

Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase
by: Timothy J. Sontag, et al.
Published: (2007-05-01)

Zeb2: A novel regulator of cardiac fibroblast to myofibroblast transition
by: Jahan, Fahmida
Published: (2016)

CYP2D6 Genotype-Based Dose Recommendations for Risperidone in Asian People
by: Yuanxia Cui, et al.
Published: (2020-08-01)

Distribution of CYP2D6 polymorphism in the Middle Eastern region
by: Zahra Khalaj, et al.
Published: (2019-01-01)

Immobilization stress increased cytochrome P450 1A2 (CYP1A2) expression in the ovary of rat
by: Jong-Chan Hwang, et al.
Published: (2021-03-01)

Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms / Mthokozisi Muziwandile Nkosingiphile Mgwabi
by: Mgwabi, Mthokozisi Muziwandile Nkosingiphile
Published: (2009)

Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms / Mthokozisi Muziwandile Nkosingiphile Mgwabi
by: Mgwabi, Mthokozisi Muziwandile Nkosingiphile
Published: (2009)

Genetic variations in the drug metabolizing enzyme, CYP2E1, among various ethnic populations of Pakistan
by: Sagheer Ahmed, et al.
Published: (2020-08-01)

Pharmacokinetics of diclofenac in healthy controls with wild-type phenotype for CYP2C9 shows metabolism variability
by: M. Martín-De Saro, et al.
Published: (2017-04-01)

Interference of Homologous Sequences on the SNP Study of CYP2A13 Gene
by: Qinghua ZHOU, et al.
Published: (2010-02-01)

THE ROLE OF THE ACE2/ANG-(1-7)/MASR AXIS IN THE DEVELOPMENT OF OBESITY-HYPERTENSION IN MALE AND FEMALE MICE
by: Wang, Yu
Published: (2016)

The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis
by: Jemima Seidenberg, et al.
Published: (2021-02-01)

Potential Mechanism of Action of Cyclosporin A in Human Dermal Fibroblasts—Transcriptomic Analysis of CYPs
by: Grażyna Janikowska, et al.
Published: (2018-07-01)

The Effects of H2S on the Activities of CYP2B6, CYP2D6, CYP3A4, CYP2C19 and CYP2C9 in Vivo in Rat
by: Xianqin Wang, et al.
Published: (2013-12-01)

CYP2J2 and EETs Protect Against Lung Ischemia/Reperfusion Injury via Anti-Inflammatory Effects in Vivo and in Vitro
by: Wenshu Chen, et al.
Published: (2015-03-01)

CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
by: Renata dos Santos Coura, et al.
Published: (2007-01-01)

ROLE OF THE CYP1A2 GENE POLYMORPHISM ON EARLY AGEING FROM OCCUPATIONAL EXPOSURE
by: Eshkoor Sa., et al.
Published: (2013-12-01)

E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene
by: Rongheng Liao, et al.
Published: (2021-01-01)

A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents
by: Thomas Dodsworth, et al.
Published: (2018-07-01)

Immunohistological expression of cytochrome P450 1A2 (CYP1A2) in the ovarian follicles of prepubertal and pubertal rat
by: Jong-Chan Hwan, et al.
Published: (2020-12-01)

PERFIL DE SENSIBILIDAD DE HEP-G2 COMO MODELO PARA EVALUACIÓN DE ACTIVIDAD CITOTÓXICA DE XENOBIÓTICOS BIOACTIVADOS VIA CYP450 SENSITIVILITY PROFILE HEP-G2 AS A MODEL OF CYTOTOXIC ACTIVITY DETERMINATION OF BIOACTIVATED XENOBIOTICS VIA CYP450
by: Stephanie O PRIETO, et al.
Published: (2009-05-01)