CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/13

CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/13

The arachidonic acid-cytochrome P450 2J2-epoxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular system. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac fibrosis from the perspective of cardiac fibroblast...

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Bibliographic Details
Main Authors: Zuowen He, Yong Yang, Zheng Wen, Chen Chen, Xizhen Xu, Yanfang Zhu, Yan Wang, Dao Wen Wang
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Lipid Research
Subjects:
cytochrome P450 2J2
cardiac fibrosis
cardiac fibroblast
α subunits of G12 family G proteins
angiotensin II
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335859

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http://www.sciencedirect.com/science/article/pii/S0022227520335859

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