Effects of ellagic acid pretreatment on renal functions disturbances induced by global cerebral ischemic-reperfusion in rat

• Main Authors: Khojasteh Hoseiny Nejad, Mohammad Kazem Gharib-Naseri, Alireza Sarkaki, Mahin Dianat, Mohammad Badavi, Yaghoub Farbood
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2017-01-01
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: BUN; Creatinine; Ellagic acid; GFR; Global cerebral ischemia; Proteinuria
• Online Access: http://ijbms.mums.ac.ir/article_8098_b75629b9d2503cb30bc01bf6b61c8a92.pdf

Objective(s): Global cerebral ischemia-reperfusion (GCIR) causes disturbances in brain functions as well as other organs such as kidney. Our aim was to evaluate the protective effects of ellagic acid (EA) on certain renal disfunction after GCIR. Materials and Methods: Adult male Wistar rats (n=32, 250-300 g) were used. GCIR was induced by bilateral vertebral and common carotid arteries occlusion (4-VO). Animal groups were: 1) received DMSO/saline (10%) as solvent of EA, 2) solvent + GCIR, 3) EA + GCIR, and 4) EA. Under anesthesia with ketamine/xylazine, GCIR was induced (20 and 30 min respectively) in related groups. EA (100 mg/kg, dissolved in DMSO/saline (10%) or solvent was administered (1.5 ml/kg) orally for 10 consecutive days to the related groups. EEG was recorded from NTS in GCIR treated groups. Results: Our data showed that: a) EEG in GCIR treated groups was flattened. b) GCIR reduced GFR (P