Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment

Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment

Oxidative stress, protein misfolding, protein complex formation, and detergent insolubility are biochemical features of Alzheimer’s disease (AD). We tested the cause-and-effect relationships among these using MC65 human neuroblastoma cells that exhibit toxicity upon conditional expression of carboxy...

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Bibliographic Details
Main Authors: Randall L. Woltjer, Wendy McMahan, Dejan Milatovic, John D. Kjerulf, Feng-Shiun Shie, Lisa G. Rung, Kathleen S. Montine, Thomas J. Montine
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer’s disease
Amyloid precursor protein
Antioxidants
Chaperones
Unfolded protein response
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002609

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http://www.sciencedirect.com/science/article/pii/S0969996106002609

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