Neural Stem Cells Reduce Hippocampal Tau and Reelin Accumulation in Aged Ts65Dn down Syndrome Mice

Neural Stem Cells Reduce Hippocampal Tau and Reelin Accumulation in Aged Ts65Dn down Syndrome Mice

Tau accumulation, in the form of neurofibrillary tangles (NFT), is an early neuropathological characteristic of Alzheimer's disease (AD) and early onset AD frequently seen in Down syndrome (DS). We investigated the presence of tau accumulation in the brains of aging DS mice using the Ts65Dn mou...

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Bibliographic Details
Main Authors:	D. S. Kern, K. N. Maclean, H. Jiang, E. Y. Synder, J. R. Sladek, K. B. Bjugstad Ph.D.
Format:	Article
Language:	English
Published:	SAGE Publishing 2011-04-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.3727/096368910X528085

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