Residential ventilation and carcinogenesis
Recent and emerging research suggests that acute exposure to CO2 levels as low as 1% alters inflammatory and immune signaling pathways independent of extra or intracellular acidosis; including those effectors that are known to be implicated in the modulation of carcinogenesis. Acute exposure to CO2...
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International Pharmaceutical Excipients Council
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| Series: | Journal of Excipients and Food Chemicals |
| Online Access: | http://jefc.scholasticahq.com/article/911-residential-ventilation-and-carcinogenesis.pdf |
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doaj-e17cc7455f3e49b7ac6f300bdea50ed42020-11-25T00:05:44ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-2668Residential ventilation and carcinogenesisShireesh ApteRecent and emerging research suggests that acute exposure to CO2 levels as low as 1% alters inflammatory and immune signaling pathways independent of extra or intracellular acidosis; including those effectors that are known to be implicated in the modulation of carcinogenesis. Acute exposure to CO2 levels as low as 600 ppm, which are commonly exceeded in indoor air, causes increased allostatic load and adverse physiological effects. Given the well-established role of oxygen sensing pathways in cancer, and the recent acidosis independent role of CO2 in modulating immune and inflammation linking pathways, it seems obligatory to validate (or not) the effects of long-term inspired elevated CO2 on the modulation of carcinogenesis.http://jefc.scholasticahq.com/article/911-residential-ventilation-and-carcinogenesis.pdf |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shireesh Apte |
| spellingShingle |
Shireesh Apte Residential ventilation and carcinogenesis Journal of Excipients and Food Chemicals |
| author_facet |
Shireesh Apte |
| author_sort |
Shireesh Apte |
| title |
Residential ventilation and carcinogenesis |
| title_short |
Residential ventilation and carcinogenesis |
| title_full |
Residential ventilation and carcinogenesis |
| title_fullStr |
Residential ventilation and carcinogenesis |
| title_full_unstemmed |
Residential ventilation and carcinogenesis |
| title_sort |
residential ventilation and carcinogenesis |
| publisher |
International Pharmaceutical Excipients Council |
| series |
Journal of Excipients and Food Chemicals |
| issn |
2150-2668 |
| description |
Recent and emerging research suggests that
acute exposure to CO2 levels as low as 1%
alters inflammatory and immune signaling
pathways independent of extra or intracellular
acidosis; including those effectors that are
known to be implicated in the modulation of
carcinogenesis. Acute exposure to CO2 levels
as low as 600 ppm, which are commonly
exceeded in indoor air, causes increased
allostatic load and adverse physiological effects.
Given the well-established role of oxygen
sensing pathways in cancer, and the recent
acidosis independent role of CO2 in modulating
immune and inflammation linking pathways, it
seems obligatory to validate (or not) the effects
of long-term inspired elevated CO2 on the
modulation of carcinogenesis. |
| url |
http://jefc.scholasticahq.com/article/911-residential-ventilation-and-carcinogenesis.pdf |
| work_keys_str_mv |
AT shireeshapte residentialventilationandcarcinogenesis |
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