Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent

Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent

This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis th...

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Bibliographic Details
Main Authors: Roberto E.P. Sica, Alejandro F. De Nicola, María C. González Deniselle, Gabriel Rodriguez, Gisella M. Gargiulo Monachelli, Liliana Martinez Peralta, Mariela Bettini
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 2011-08-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
esclerosis lateral amiotrófica
esclerosis lateral amiotrófica esporádica
patogenia
astrocito
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500023&lng=en&tlng=en

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