The Most Common Vitamin D Receptor Polymorphisms (<i>ApaI,</i><i>FokI</i>, <i>TaqI</i>, <i>BsmI</i>, and <i>BglI</i>) in Children with Dental Caries: A Systematic Review and Meta-Analysis

• Main Authors: Masoud Sadeghi, Amin Golshah, Mostafa Godiny, Roohollah Sharifi, Atefeh Khavid, Nafiseh Nikkerdar, Santosh Kumar Tadakamadla
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Children
• Subjects: dental caries; tooth decay; polymorphism; vitamin D; meta-analysis
• Online Access: https://www.mdpi.com/2227-9067/8/4/302

Vitamin D participates in the calcification of enamel and dentin and the appropriate immune responses to oral microbial infections. We aimed to assess the association between the most common vitamin D receptor (<i>VDR</i>) polymorphisms (<i>ApaI,</i><i>FokI</i>, <i>TaqI</i>, <i>BsmI</i>, and <i>BglI</i>) and the risk of dental caries in children. Methods: PubMed/MEDLINE, Cochrane Library, Web of Science, and Scopus databases were comprehensively searched until 19 January 2021. Meta-analysis with odds ratios as the effect estimate along with 95% confidence intervals and subgroup analysis were conducted using Review Manager 5.3 software. Publication bias and sensitivity analyses were conducted by Comprehensive Meta-Analysis, version 2.0 software. Results: Seventy-eight studies were retrieved from the databases, with nine studies included in the final analysis. Based on five genetic models, there was no association between <i>ApaI (rs7975232)</i>, <i>TaqI (rs731236)</i>, <i>BsmI (rs1544410)</i>, <i>FokI (rs2228570)</i>, and <i>BglI (rs739837)</i> polymorphisms and susceptibility to dental caries, except for the <i>FokI (rs10735810)</i> polymorphism. Conclusion: Among the <i>VDR</i> polymorphisms considered, an association was found between the <i>FokI (rs10735810)</i> polymorphism and the risk of dental caries, with a protective role of the f allele and ff genotype.