Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections

Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections

Abstract Background Plasmodium falciparum (Pf) sporozoites (PfSPZ) can be administered as a highly protective vaccine conferring the highest protection seen to date. Sanaria® PfSPZ vaccines are produced using aseptically reared Anopheles stephensi mosquitoes. The bionomics of sporogonic development...

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Bibliographic Details
Main Authors: Peter F. Billingsley, Kasim I. George, Abraham G. Eappen, Robert A. Harrell, Robert Alford, Tao Li, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, David A. O’Brochta
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Malaria Journal
Subjects:
Anopheles stephensi
Mosquito
Immune system
Gene silencing
Plasmodium falciparum
Oocyst
Online Access:https://doi.org/10.1186/s12936-021-03818-8

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