Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits

Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits

<p>Abstract</p> <p>Background</p> <p>In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, w...

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Main Authors: Partanen Jukka, Saavalainen Päivi, Lohi Olli, Korponay-Szabo Ilma R, Lindfors Katri, Stenman Satumarja M, Haimila Katri, Wieser Herbert, Mäki Markku, Kaukinen Katri
Format: Article
Language:English
Published: BMC 2008-02-01
Series:BMC Immunology
Online Access:http://www.biomedcentral.com/1471-2172/9/6

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