Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence

Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence

The recurrence of glioma is a difficult problem in clinical treatment. The molecular markers of primary tumors after resection cannot fully represent the characteristics of recurrent tumors. Here, abundant tumor DNA was detected in tumor in situ fluid (TISF). We report that TISF-derived tumor DNA (T...

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Bibliographic Details
Main Authors: Jinliang Yu, Zhiyuan Sheng, Shuang Wu, Yushuai Gao, Zhaoyue Yan, Chaojie Bu, Jianjun Gu, Yage Bu, Kaiyuan Deng, Sensen Xu, Zhongcan Chen, Zhang Qianqian, Zenmar Ajmal, Juha Hernesniemi, Meiyun Wang, Gang Liu, Tianxiao Li, Xingyao Bu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
precision medicine
tumor in-situ fluid
circulating tumor DNA
spatiotemporal heterogeneity
glioma progression
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.742037/full

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