Roles of Extracellular Vesicles in Metastatic Breast Cancer

Roles of Extracellular Vesicles in Metastatic Breast Cancer

Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with m...

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Main Authors: Junya Peng, Wenqian Wang, Surong Hua, Lulu Liu
Format: Article
Language:English
Published: SAGE Publishing 2018-04-01
Series:Breast Cancer: Basic and Clinical Research
Online Access:https://doi.org/10.1177/1178223418767666
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spelling doaj-e1484b71259e48659fcc4c89160768f42020-11-25T03:24:17ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342018-04-011210.1177/1178223418767666Roles of Extracellular Vesicles in Metastatic Breast CancerJunya Peng0Wenqian Wang1Surong Hua2Lulu Liu3Department of Center Lab, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, ChinaSchool of Medicine, Tsinghua University, Beijing, ChinaDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, ChinaDepartment of Center Lab, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, ChinaCells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. This review also covers EV roles as biomarker and therapeutic target in clinical application.https://doi.org/10.1177/1178223418767666
collection DOAJ
language English
format Article
sources DOAJ
author Junya Peng
Wenqian Wang
Surong Hua
Lulu Liu
spellingShingle Junya Peng
Wenqian Wang
Surong Hua
Lulu Liu
Roles of Extracellular Vesicles in Metastatic Breast Cancer
Breast Cancer: Basic and Clinical Research
author_facet Junya Peng
Wenqian Wang
Surong Hua
Lulu Liu
author_sort Junya Peng
title Roles of Extracellular Vesicles in Metastatic Breast Cancer
title_short Roles of Extracellular Vesicles in Metastatic Breast Cancer
title_full Roles of Extracellular Vesicles in Metastatic Breast Cancer
title_fullStr Roles of Extracellular Vesicles in Metastatic Breast Cancer
title_full_unstemmed Roles of Extracellular Vesicles in Metastatic Breast Cancer
title_sort roles of extracellular vesicles in metastatic breast cancer
publisher SAGE Publishing
series Breast Cancer: Basic and Clinical Research
issn 1178-2234
publishDate 2018-04-01
description Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. This review also covers EV roles as biomarker and therapeutic target in clinical application.
url https://doi.org/10.1177/1178223418767666
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AT wenqianwang rolesofextracellularvesiclesinmetastaticbreastcancer
AT suronghua rolesofextracellularvesiclesinmetastaticbreastcancer
AT lululiu rolesofextracellularvesiclesinmetastaticbreastcancer
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