Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma

Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma

Emerging evidence indicates that the activity of pyruvate kinase M2 (PKM2) isoform is crucial for the survival of tumor cells. However, the molecular mechanism underlying the function of PKM2 in renal cancer is undetermined. Here, we reveal the overexpression of PKM2 in the proximal tubule of renal...

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Bibliographic Details
Main Authors: Prasanta Dey, Ji Yeon Son, Amit Kundu, Kyeong Seok Kim, Yura Lee, Kyungsil Yoon, Sungpil Yoon, Byung Mu Lee, Ki Taek Nam, Hyung Sik Kim
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
pyruvate kinase m2
autophagy
metabolism
migration
invasion
Online Access:https://www.mdpi.com/1422-0067/20/22/5622

Internet

https://www.mdpi.com/1422-0067/20/22/5622

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