No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing.Questionnaires regarding sex...

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Main Authors: Elgar Susanne Quabius, Asita Fazel, Christopher Knieling, Stephan Gebhardt, Martin Laudien, Crystal Moore, André Kühnel, Florian Hoppe, Robert Mlynski, Alessa Heinrichs, Alexander Fabian, Markus Hoffmann
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Papillomavirus Research
Subjects:
HPV
Oral
Sexual behavior
Oral sex
STD
Infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2405852120300173
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spelling doaj-e13c2e1b9a8e49e0b1633cb968cd025a2020-12-17T04:50:30ZengElsevierPapillomavirus Research2405-85212020-12-0110100207No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesisElgar Susanne Quabius0Asita Fazel1Christopher Knieling2Stephan Gebhardt3Martin Laudien4Crystal Moore5André Kühnel6Florian Hoppe7Robert Mlynski8Alessa Heinrichs9Alexander Fabian10Markus Hoffmann11Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 3, Building 27, D-24105, Kiel, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 3, Building 27, D-24105, Kiel, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 3, Building 27, D-24105, Kiel, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 3, Building 27, D-24105, Kiel, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 3, Building 27, D-24105, Kiel, GermanyEnvironment Agency, 2 Marsham Street, London, SW1P 4DF, UKDepartment of Otorhinolaryngology, Head and Neck Surgery, Asklepios Hospital Harburg, Eißendorfer Pferdeweg 52, D-21075, Hamburg, GermanyDepartment of Otorhinolaryngology-Head and Neck Surgery, Klinikum Oldenburg, Rahel-Straus-Straße 10, D-26133, Oldenburg, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Str. 137-139, D-18057, Rostock, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Str. 137-139, D-18057, Rostock, GermanyDepartment of Radiooncology, Christian-Albrechts-University, Arnold-Heller-Str, 3 Building, D-24105, Kiel, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University, Arnold-Heller-Str. 3, Building 27, D-24105, Kiel, Germany; Corresponding author.HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing.Questionnaires regarding sexual behavior, education tobacco- and alcohol-consumption, were given to 28 patients with tonsillar hyperplasia (H) and 128 patients with tonsillar carcinomas (CA), all with tissue-typed HPV-DNA-status performing PCR. Answers were correlated among groups and HPV-status.106 questionnaires were analyzed. Comparisons between H- (n = 25) and CA- (n = 81) patients showed that CA-patients were older (61.1yrs ± 9.3) than H-patients (45.2yrs ± 11.9; p < 0.0001; Student's t-test); had a lower educational level (p = 0.0095); and lower number of sexual partners (p = 0.0222; Fisher's exact test). All groups showed a significant correlation between smoking and lack of HPV-DNA-positivity (p = 0.001). Further Fisher's exact tests and logistic regression analysis revealed in all 106 patients no significant correlations between tissue-HPV-status and the analyzed parameters.Despite the limited sample size, we were able to confirm the established correlation between smoking and tissue-HPV-status. The correlation between sexual behavior and HPV-infection was not confirmed. No consensus exists in the literature about the latter. Our data does not support the strict classification of oral HPV-infections and HPV-driven HNSCCs as STDs.http://www.sciencedirect.com/science/article/pii/S2405852120300173HPVOralSexual behaviorOral sexSTDInfection
collection DOAJ
language English
format Article
sources DOAJ
author Elgar Susanne Quabius
Asita Fazel
Christopher Knieling
Stephan Gebhardt
Martin Laudien
Crystal Moore
André Kühnel
Florian Hoppe
Robert Mlynski
Alessa Heinrichs
Alexander Fabian
Markus Hoffmann
spellingShingle Elgar Susanne Quabius
Asita Fazel
Christopher Knieling
Stephan Gebhardt
Martin Laudien
Crystal Moore
André Kühnel
Florian Hoppe
Robert Mlynski
Alessa Heinrichs
Alexander Fabian
Markus Hoffmann
No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis
Papillomavirus Research
HPV
Oral
Sexual behavior
Oral sex
STD
Infection
author_facet Elgar Susanne Quabius
Asita Fazel
Christopher Knieling
Stephan Gebhardt
Martin Laudien
Crystal Moore
André Kühnel
Florian Hoppe
Robert Mlynski
Alessa Heinrichs
Alexander Fabian
Markus Hoffmann
author_sort Elgar Susanne Quabius
title No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis
title_short No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis
title_full No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis
title_fullStr No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis
title_full_unstemmed No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis
title_sort no association between hpv-status in tonsillar tissue and sexual behavior of the patients in a northern german population - critical view of the link between hpv natural history and hpv-driven carcinogenesis
publisher Elsevier
series Papillomavirus Research
issn 2405-8521
publishDate 2020-12-01
description HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing.Questionnaires regarding sexual behavior, education tobacco- and alcohol-consumption, were given to 28 patients with tonsillar hyperplasia (H) and 128 patients with tonsillar carcinomas (CA), all with tissue-typed HPV-DNA-status performing PCR. Answers were correlated among groups and HPV-status.106 questionnaires were analyzed. Comparisons between H- (n = 25) and CA- (n = 81) patients showed that CA-patients were older (61.1yrs ± 9.3) than H-patients (45.2yrs ± 11.9; p < 0.0001; Student's t-test); had a lower educational level (p = 0.0095); and lower number of sexual partners (p = 0.0222; Fisher's exact test). All groups showed a significant correlation between smoking and lack of HPV-DNA-positivity (p = 0.001). Further Fisher's exact tests and logistic regression analysis revealed in all 106 patients no significant correlations between tissue-HPV-status and the analyzed parameters.Despite the limited sample size, we were able to confirm the established correlation between smoking and tissue-HPV-status. The correlation between sexual behavior and HPV-infection was not confirmed. No consensus exists in the literature about the latter. Our data does not support the strict classification of oral HPV-infections and HPV-driven HNSCCs as STDs.
topic HPV
Oral
Sexual behavior
Oral sex
STD
Infection
url http://www.sciencedirect.com/science/article/pii/S2405852120300173
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