Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic da...

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Main Authors:	Hongjing Dong, Yanling Geng, Xueyong Wang, Xiangyun Song, Xiao Wang, Jinqian Yu
Format:	Article
Language:	English
Published:	MDPI AG 2018-10-01
Series:	Molecules
Subjects:	Scindapsus officinalis monoterpene glycoside phenyl glycoside caffeoyl derivative anti-inflammatory activity
Online Access:	http://www.mdpi.com/1420-3049/23/10/2577

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spelling	doaj-e1364069b7dc4896bfd440338b8a38132020-11-24T21:34:42ZengMDPI AGMolecules1420-30492018-10-012310257710.3390/molecules23102577molecules23102577Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory ActivitiesHongjing Dong0Yanling Geng1Xueyong Wang2Xiangyun Song3Xiao Wang4Jinqian Yu5Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaCollege of Chinese Mareria Medica, Beijing University of Chinese Medicine, Beijing 100102, ChinaShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, ChinaOne new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC50 values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.http://www.mdpi.com/1420-3049/23/10/2577Scindapsus officinalismonoterpene glycosidephenyl glycosidecaffeoyl derivativeanti-inflammatory activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hongjing Dong Yanling Geng Xueyong Wang Xiangyun Song Xiao Wang Jinqian Yu
spellingShingle	Hongjing Dong Yanling Geng Xueyong Wang Xiangyun Song Xiao Wang Jinqian Yu Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities Molecules Scindapsus officinalis monoterpene glycoside phenyl glycoside caffeoyl derivative anti-inflammatory activity
author_facet	Hongjing Dong Yanling Geng Xueyong Wang Xiangyun Song Xiao Wang Jinqian Yu
author_sort	Hongjing Dong
title	Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_short	Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_full	Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_fullStr	Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_full_unstemmed	Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities
title_sort	chemical constituents from scindapsus officinalis (roxb.) schott. and their anti–inflammatory activities
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2018-10-01
description	One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC50 values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.
topic	Scindapsus officinalis monoterpene glycoside phenyl glycoside caffeoyl derivative anti-inflammatory activity
url	http://www.mdpi.com/1420-3049/23/10/2577
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Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

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