Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk

Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk

Summary: The innate immune system responds to infections that give rise to pain. How the innate immune system interacts with the sensory nervous system and contributes to pain is poorly understood. Here we report that hyperactivity of innate immunity primes and initiates pain states via the TLR2-int...

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Bibliographic Details
Main Authors: Junting Huang, Maria A. Gandini, Lina Chen, Said M’Dahoma, Patrick L. Stemkowski, Hyunjae Chung, Daniel A. Muruve, Gerald W. Zamponi
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
innate immunity
TLR2
NLRP3
IL-33/ST2
sensory neurons
pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312225

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