Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine

• Main Authors: Michael Sheyner, Seong-Jin Yu, Yun Wang
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Brain Circulation
• Subjects: Co-grafts; cyclosporine-A; immunorejection; nanoVeh; nanoparticles; Parkinson's disease; stem cells; trophic factors; Wharton's jelly mesenchymal stem cells; xenografts
• Online Access: http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=3;spage=130;epage=133;aulast=Sheyner

A major limitation with cell transplantation in patients is the unimpressive number of cells survived. The death of grafted cells involves apoptosis and immunorejection. In this review, we encapsulate the recent preclinical development that improves the survival of grafted cells and mitigates the immunorejection of human-induced pluripotent stem cells (iPSCs) through co-grating nanoparticles-containing cyclosporine A (NanoCsA) in hemiparkinsonian rats. The study supported the notion that NanoCsA allows for long-lasting CsA discharge and limits immunorejection of human iPSC xenograft in a 6-hydroxydopamine Parkinson's disease rat model.