Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin.

Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin.

The plant secondary metabolite and common food additive dihydrocoumarin (DHC) is an inhibitor of the Sirtuin family of NAD+-dependent deacetylases. Sirtuins are key regulators of epigenetic processes that maintain silent chromatin in yeast and have been linked to gene expression, metabolism, apoptos...

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Bibliographic Details
Main Authors: Jennifer L Jacobi, Bo Yang, Xu Li, Anna K Menze, Sara M Laurentz, Elsa M Janle, Mario G Ferruzzi, George P McCabe, Clint Chapple, Ann L Kirchmaier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4755582?pdf=render

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