Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages
It has been suggested that the oxidative modification of low density lipoprotein (LDL) is a key event in atherogenesis. Several mechanisms have been proposed to explain how different types of cells modify LDL. In this study we examine the relative contributions of superoxide anions and cellular lipo...
Main Authors: | SM Rankin, S Parthasarathy, D Steinberg |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
1991-03-01
|
Series: | Journal of Lipid Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520420681 |
Similar Items
-
Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase.
by: M Ezaki, et al.
Published: (1995-09-01) -
Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions
by: Dagmar Heydeck, et al.
Published: (2001-07-01) -
Assessment of 5-lipoxygenase involvement in human monocyte-mediated LDL oxidation.
by: VA Folcik, et al.
Published: (1993-01-01) -
Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids
by: J M Upston, et al.
Published: (1996-12-01) -
Mechanisms of enhanced macrophage apoE secretion by oxidized LDL
by: A A Cader, et al.
Published: (1997-05-01)