Edition of TFAM gene by CRISPR/Cas9 technology in bovine model.

Edition of TFAM gene by CRISPR/Cas9 technology in bovine model.

The mitochondrial transcription factor A (TFAM) is a mitochondrial DNA (mtDNA) binding protein essential for the initiation of transcription and genome maintenance. Recently it was demonstrated that the primary role of TFAM is to maintain the integrity of mtDNA and that it is a key regulator of mtDN...

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Main Authors: Vanessa Cristina de Oliveira, Gabriel Sassarão Alves Moreira, Fabiana Fernandes Bressan, Clésio Gomes Mariano Junior, Kelly Cristine Santos Roballo, Marine Charpentier, Jean-Paul Concordet, Flávio Vieira Meirelles, Carlos Eduardo Ambrósio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213376

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