Atypical Cardiac Location of Melanoma of Unknown Origin

Atypical Cardiac Location of Melanoma of Unknown Origin

The subject was a 66-year-old woman, suffering from the chest pain evoked by physical activity. Transthoracic echocardiography (TTE) revealed an abnormal structure, 41 × 29 mm. In MSCT, a hypodensic mobile tissue lesion that was infiltrating the whole thickness of left ventricle was confirmed. PET e...

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Main Authors: Agnieszka Styczeń, Mariusz Kozak, Marta Karaś-Głodek, Elżbieta Czekajska-Chehab, Andrzej Tomaszewski, Andrzej Wysokiński, Tomasz Zapolski
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Medicina
Subjects:
64-slice multidetector computed tomography
echocardiogram
melanoma malignum
pembrolizumab
Online Access:https://www.mdpi.com/1010-660X/57/2/107
id doaj-e11cb8bcef5f4e9f853c975ec1e836ae
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spelling doaj-e11cb8bcef5f4e9f853c975ec1e836ae2021-01-26T00:00:59ZengMDPI AGMedicina1010-660X2021-01-015710710710.3390/medicina57020107Atypical Cardiac Location of Melanoma of Unknown OriginAgnieszka Styczeń0Mariusz Kozak1Marta Karaś-Głodek2Elżbieta Czekajska-Chehab3Andrzej Tomaszewski4Andrzej Wysokiński5Tomasz Zapolski6Department of Cardiology, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Cardiology, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Cardiology, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Radiology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Cardiology, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Cardiology, Medical University of Lublin, 20-954 Lublin, PolandDepartment of Cardiology, Medical University of Lublin, 20-954 Lublin, PolandThe subject was a 66-year-old woman, suffering from the chest pain evoked by physical activity. Transthoracic echocardiography (TTE) revealed an abnormal structure, 41 × 29 mm. In MSCT, a hypodensic mobile tissue lesion that was infiltrating the whole thickness of left ventricle was confirmed. PET excluded the existence of other remote lesions. After surgical tumor removal, histopathological differential diagnosis revealed melanoma, myoepithelial cancer, and MPNST “high–grade” sarcoma. A control TTE detected a tumor that was 14 × 10 mm. After immunohistochemical results, immunotherapy with pembrolizumab was used, which resulted in complete tumor resolution. Presently, surgical resection and neoadjuvant targeted immunochemotherapy remain the treatment of choice for clinical stage III/IV melanoma.https://www.mdpi.com/1010-660X/57/2/10764-slice multidetector computed tomographyechocardiogrammelanoma malignumpembrolizumab
collection DOAJ
language English
format Article
sources DOAJ
author Agnieszka Styczeń
Mariusz Kozak
Marta Karaś-Głodek
Elżbieta Czekajska-Chehab
Andrzej Tomaszewski
Andrzej Wysokiński
Tomasz Zapolski
spellingShingle Agnieszka Styczeń
Mariusz Kozak
Marta Karaś-Głodek
Elżbieta Czekajska-Chehab
Andrzej Tomaszewski
Andrzej Wysokiński
Tomasz Zapolski
Atypical Cardiac Location of Melanoma of Unknown Origin
Medicina
64-slice multidetector computed tomography
echocardiogram
melanoma malignum
pembrolizumab
author_facet Agnieszka Styczeń
Mariusz Kozak
Marta Karaś-Głodek
Elżbieta Czekajska-Chehab
Andrzej Tomaszewski
Andrzej Wysokiński
Tomasz Zapolski
author_sort Agnieszka Styczeń
title Atypical Cardiac Location of Melanoma of Unknown Origin
title_short Atypical Cardiac Location of Melanoma of Unknown Origin
title_full Atypical Cardiac Location of Melanoma of Unknown Origin
title_fullStr Atypical Cardiac Location of Melanoma of Unknown Origin
title_full_unstemmed Atypical Cardiac Location of Melanoma of Unknown Origin
title_sort atypical cardiac location of melanoma of unknown origin
publisher MDPI AG
series Medicina
issn 1010-660X
publishDate 2021-01-01
description The subject was a 66-year-old woman, suffering from the chest pain evoked by physical activity. Transthoracic echocardiography (TTE) revealed an abnormal structure, 41 × 29 mm. In MSCT, a hypodensic mobile tissue lesion that was infiltrating the whole thickness of left ventricle was confirmed. PET excluded the existence of other remote lesions. After surgical tumor removal, histopathological differential diagnosis revealed melanoma, myoepithelial cancer, and MPNST “high–grade” sarcoma. A control TTE detected a tumor that was 14 × 10 mm. After immunohistochemical results, immunotherapy with pembrolizumab was used, which resulted in complete tumor resolution. Presently, surgical resection and neoadjuvant targeted immunochemotherapy remain the treatment of choice for clinical stage III/IV melanoma.
topic 64-slice multidetector computed tomography
echocardiogram
melanoma malignum
pembrolizumab
url https://www.mdpi.com/1010-660X/57/2/107
work_keys_str_mv AT agnieszkastyczen atypicalcardiaclocationofmelanomaofunknownorigin
AT mariuszkozak atypicalcardiaclocationofmelanomaofunknownorigin
AT martakarasgłodek atypicalcardiaclocationofmelanomaofunknownorigin
AT elzbietaczekajskachehab atypicalcardiaclocationofmelanomaofunknownorigin
AT andrzejtomaszewski atypicalcardiaclocationofmelanomaofunknownorigin
AT andrzejwysokinski atypicalcardiaclocationofmelanomaofunknownorigin
AT tomaszzapolski atypicalcardiaclocationofmelanomaofunknownorigin
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