Tumor versus stromal cells in culture--survival of the fittest?

Tumor versus stromal cells in culture--survival of the fittest?

Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for example, occurs in 40 to 50% of GBM, and yet, EGFR amplification is rarely preserved in cell cultures derived from hum...

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Bibliographic Details
Main Authors: Krishna M Talasila, Narve Brekka, Kjersti Mangseth, Daniel Stieber, Lasse Evensen, Gro V Rosland, Anja Torsvik, Marek Wagner, Simone P Niclou, Rupavathana Mahesparan, Olav K Vintermyr, Rolf Bjerkvig, Janice M Nigro, Hrvoje Miletic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349039/?tool=EBI

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