Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.

Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.

Cadherin-17 (CDH17), one member of 7D-cadherin superfamily, was overexpressed in gastric cancer (GC) and was associated with poor survival, tumor recurrence, metastasis, and advanced tumor stage. So far the cellular function and signaling mechanism of CDH17 in GC remains unclear. In this study, we s...

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Bibliographic Details
Main Authors: Zhaohu Lin, Chao Zhang, Meifang Zhang, Danqing Xu, Yanfen Fang, Zheng Zhou, Xiaolong Chen, Ning Qin, Xiongwen Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3896370?pdf=render

Internet

http://europepmc.org/articles/PMC3896370?pdf=render

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