The occurrence of cancer in vertebrates: a mini review

• Main Authors: Christos V. Kitsoulis, Athanasios D. Baxevanis, Theodore J. Abatzopoulos
• Format: Article
• Language: English
• Published: BMC 2020-06-01
• Series: Journal of Biological Research - Thessaloniki
• Subjects: Neoplasia; Cancer; Animal taxa; Vertebrates; Evolution; Phenotype
• Online Access: http://link.springer.com/article/10.1186/s40709-020-00119-0

Abstract Neoplasia is a multilevel condition caused by irregularities over the genome, which can lead to a fatal result. To fully understand this phenomenon, an evolutionary challenge has risen during the last decades, away from human limits, driving the scientific quest into the wild life. The study of wild vertebrate populations in their natural habitats has shown that cancer is rather prominent. Thus, the diversity of vertebrates reported with some form of neoplasia is quite scattered through a variety of habitats. However, some species constitute exceptions by exhibiting cancer-protective features, driven by certain loci in their DNA. It is obvious that from an evolutionary standpoint, the incidence of cancer in different taxa is nowadays studied by seeking for patterns and their roots. The main purpose of the evolutionary approach is no other than to answer a fundamental question: Could cancer be ultimately regarded as another evolutionary force conducive to the formation or shaping-up of species?