Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease

Abstract Background Three amino acid differences between rodent and human APP affect medically important features, including β-secretase cleavage of APP and Aβ peptide aggregation (De Strooper et al., EMBO J 14:4932-38, 1995; Ueno et al., Biochemistry 53:7523-30, 2014; Bush, 2003, Trends Neurosci 26...

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Bibliographic Details
Main Authors: Lutgarde Serneels, Dries T’Syen, Laura Perez-Benito, Tom Theys, Matthew G. Holt, Bart De Strooper
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Neurodegeneration
Subjects:
Knock-in
Rodent animal models
Alzheimer’s disease
Amyloid-beta precursor protein
Presenilin
Online Access:http://link.springer.com/article/10.1186/s13024-020-00399-z

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