Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus
Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Re...
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MDPI AG
2021-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/2/211 |
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doaj-e0fda59072e34a63aa5a88a15d8f570a2021-01-31T00:01:52ZengMDPI AGViruses1999-49152021-01-011321121110.3390/v13020211Three-Dimensional Cell Culture Systems for Studying Hepatitis C VirusChui-Wa So0Glenn Randall1Department of Microbiology, The University of Chicago, Chicago, IL 60637, USADepartment of Microbiology, The University of Chicago, Chicago, IL 60637, USAHepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Researchers have begun adapting these cell culture models that morphologically and physiologically resemble hepatocytes in vivo to study HCV infection. This review summarizes the use of three-dimensional cell culture systems in studies of HCV infection.https://www.mdpi.com/1999-4915/13/2/211hepatitis C virusorganoids3Dpolarization |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chui-Wa So Glenn Randall |
| spellingShingle |
Chui-Wa So Glenn Randall Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus Viruses hepatitis C virus organoids 3D polarization |
| author_facet |
Chui-Wa So Glenn Randall |
| author_sort |
Chui-Wa So |
| title |
Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus |
| title_short |
Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus |
| title_full |
Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus |
| title_fullStr |
Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus |
| title_full_unstemmed |
Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus |
| title_sort |
three-dimensional cell culture systems for studying hepatitis c virus |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2021-01-01 |
| description |
Hepatocytes, the major target of hepatitis C virus (HCV), are highly polarized. HCV infection requires extensive trafficking to distinct subcellular domains in the polarized hepatocyte. Polarized cells and three-dimensional organoids are commonly used to study liver functions and differentiation. Researchers have begun adapting these cell culture models that morphologically and physiologically resemble hepatocytes in vivo to study HCV infection. This review summarizes the use of three-dimensional cell culture systems in studies of HCV infection. |
| topic |
hepatitis C virus organoids 3D polarization |
| url |
https://www.mdpi.com/1999-4915/13/2/211 |
| work_keys_str_mv |
AT chuiwaso threedimensionalcellculturesystemsforstudyinghepatitiscvirus AT glennrandall threedimensionalcellculturesystemsforstudyinghepatitiscvirus |
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