Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit During Gestation

Profiling of Tryptophan Metabolic Pathways in the Rat Fetoplacental Unit During Gestation

Placental homeostasis of tryptophan is essential for fetal development and programming. The two main metabolic pathways (serotonin and kynurenine) produce bioactive metabolites with immunosuppressive, neurotoxic, or neuroprotective properties and their concentrations in the fetoplacental unit must b...

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Bibliographic Details
Main Authors: Cilia Abad, Rona Karahoda, Petr Kastner, Ramon Portillo, Hana Horackova, Radim Kucera, Petr Nachtigal, Frantisek Staud
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
fetal programming
tryptophan metabolism
rat model
fetal organs
pregnancy
placenta–brain axis
Online Access:https://www.mdpi.com/1422-0067/21/20/7578

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