SUMOylation of FOXM1B Alters Its Transcriptional Activity on Regulation of MiR-200 Family and JNK1 in MCF7 Human Breast Cancer Cells

SUMOylation of FOXM1B Alters Its Transcriptional Activity on Regulation of MiR-200 Family and JNK1 in MCF7 Human Breast Cancer Cells

Transcription factor Forkhead Box Protein M1 (FOXM1) is a well-known master regulator in controlling cell-cycle pathways essential for DNA replication and mitosis, as well as cell proliferation. Among the three major isoforms of FOXM1, FOXM1B is highly associated with tumor growth and metastasis. Th...

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Bibliographic Details
Main Authors: Chiung-Min Wang, Runhua Liu, Lizhong Wang, Leticia Nascimento, Victoria C. Brennan, Wei-Hsiung Yang
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:International Journal of Molecular Sciences
Subjects:
FOXM1
SUMOylation
transcriptional activity
MiR-200b/c
JNK1
Online Access:http://www.mdpi.com/1422-0067/15/6/10233

Internet

http://www.mdpi.com/1422-0067/15/6/10233

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